Ac201080000, ac20108, ac201084000, ac201088000 synonyms. Transport information land transport us dot no data available. Diisobutylaluminum hydride reducing agent is commonly used for the reduction of an ester to aldehyde. One reagent lane fair lawn, nj 07410 for information in north america, call. A registration number is not available for this substance as the substance. Toluene crosses the placenta and is excreted in breast milk. Diisobutylaluminium hydride substance information echa. Fire hazard, immediate acute health hazard, delayed chronic health hazard.
Before handling any pyrophoric material, researchers must also read and sign the quenching of. Reduction of substituted amides to aldehydes and amines with. Predicted data is generated using the us environmental protection agencys episuite. Diisobutylaluminum hydride 1, more commonly known as dibal or dibalh, is a reducing agent dibal can be used to reduce many a functional group, but it is most commonly used to reduce carboxylic acid esters to aldehydes, which can not be done using lithium aluminumhydride, the traditional reducing agent used to reduce carbonyl compounds eg. First aid measures general advice if inhaled msds number. This organoaluminium compound was investigated originally as a cocatalyst for the polymerization of alkenes. Safety data sheet paratoluene sulfonic acid date prepared. A system of local andor general exhaust is recommended to keep employee exposures as low as possible. Material safety data sheet acros organics bvba acros. Show this safety data sheet to the doctor in attendance. Uses advised against not for food, drug, pesticide or biocidal product use details of the supplier of.
If inhaled if breathed in, move person into fresh air. Indication of any immediate medical attention and special treatment needed. Diisobutylaluminum hydride dibalh is an organoaluminum reagent typically used for the reduction esters or nitriles to aldehydes. Risk phrases safety phrases r11 highly flammable r22 harmful if swallowed r3638 irritating to the eyes and skin r63 possible risk of health to unborn child r67 vapours may cause drowsiness s36 wear suitable clothing. Material safety data sheet diisobutylaluminum hydride, 20 wt. Procedures for safe use of pyrophoric solids, 22009 page 3 of 4 specific recommendations for working with pyrophoric solid reagents lithium aluminum hydride reacts violently with water and has a significant heat of solvation. Diisobutylaluminum hydride readily reduces di and monosubstituted amides to the corresponding amines. Show this safety data sheet to the doctor in attend ance. Description toluene is a clear, colorless, volatile liquid with a sweet, pungent, benzenelike odor. Toluene 108883 toluene in blood prior to last shift of workweek 0. Toluene wt, % min 99,2 benzene wt, % max 0,02 sulphur wt, % 0,25 section 3. It is flammable at temperatures greater than 40 ef 4.
The hazard classification and labelling section shows the hazards of a substance based on the standardised system of statements and pictograms established under the clp classification labelling and packaging regulation. Slightly hazardous in case of skin contact permeator. Toluene mixes readily with many organic solvents, but. Material safety data sheet diisobutylaluminum hydridedibalh. Originally used as a cocatalyst in the zieglernatta polymerization of olefins, diisobutylaluminum hydride dibah is used as a reducing agent in the manufacturer of fine organic chemicals, flavors. Dibenzyl toluene 26898 17 9 5 10 trade secret cristobalite 14464 46 1 1 5 trade secret diatomaceous earth 68855 54 9 1 5 trade secret 1dodecylimidazole 4303 67 7 1m solution in hexane, acroseal, acros organics 100ml. Similar results can sometimes also be achieved with nanoparticles and by thin film deposition. Toluene c6h5ch3 methylbenzene, phenylmethane, toluol, ac9165, ac9165sc, ac9165pg, gd9165, ac9165p, ac9165t, ac9166, m12099, 92368, 92362, 92376 for laboratory use only. Pyrophorics pyr and selfheating substances and mixtures. Ingredients material safety data sheet synonyms chemical formula material uses 3 whmis protective clothing tdg.
Used in pdcatalyzed reductive debromination of secondary alkyl bromides. Symptoms of poisoning may appear several hours later. Reduction of substituted amides to aldehydes and amines. Diisobutylaluminium hydride dibalh, dibal, dibalh or dibah. Hazards identification potential acute health effects. If unconscious place in recovery position and seek medical advice. Chemical product and company identification product name. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Diisobutylaluminum hydride solution 1m in toluene has been used for the reduction of aziridine esters to the corresponding aldehydes. Toluene 99 108883 ingredient name % cas number there are no additional ingredients present which, within the current knowledge of the supplier and in the concentrations applicable, are classified as hazardous to health or the environment and hence require reporting in this section. Material safety data sheet acros organics bvba acros organics. First aid measures general advice consult a physician.
Used to reduce an ester or a nitrile to an aldehyde. Acroseal glass bottle packed in tin can diisobutylaluminium hydride, 1m. Safety data sheet according to 29cfr19101200 and ghs rev. The clp regulation makes sure that the hazards presented by chemicals are. Adequate ventilation to ensure that occupational exposure limits are not exceeded. Toluene is classified as dangerous goods according to the australian code for the transport of dangerous goods by road and rail. Firstaid measures general advice show this safety data sheet to the doctor in attendance. Safety data sheet northwest missouri state university.
Toluene sara 3112 msds distribution chemical inventory hazard identification. L14718 diisobutylaluminum hydride, 1m solution in toluene. Pyrophorics pyr and selfheating substances and mixtures h250 h251 h252 examples. See actual entry in rtecs for complete information. Toxic by inhalation, in contact w ith skin and if swallowed. Diisobutylaluminum hydride permanent link for this species. Diisobutylaluminum hydride 1, more commonly known as dibal or dibalh, is a reducing agent dibal can be used to reduce many a functional group, but it is most commonly used to reduce carboxylic acid esters to aldehydes, which can not be done using lithium aluminumhydride, the traditional reducing agent used to reduce carbonyl compounds. Diisobutylaluminium hydride, 1m solution in hexane. Combustion products may include carbon oxides or other toxic vapors. An organometallic compound featuring an aluminum atom bonded to a hydrogen atom and to two isobutyl groups. Suppliers list, emailrfq form, molecular structure, weight, formula, iupac, synonyms for diisobutylaluminum hydride cas no.
Unlikely under normal occupational exposures, but swallowing a minor amount may result in nausea, vomiting, shortness of breath, headache, diarrhoea and abdominal discomfort. The toxicological properties have not been fully investigated. Material safety data sheet diisobutylaluminum hydride. Diisobutylaluminum hydride not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. The products of degradation are less toxic than the product itself.
Some of the advantages of using dibalh over other organoaluminum. Diisobutylaluminum hydride reduces disubstituted amides to the corresponding aldehydes in satisfactory yield. It has also been used in the synthesis of dialkylaluminum alkoxides from alcohols. Instead, slowly add lialh 4 to anhydrous solvent in the reaction flask.
Frozen bromine trifluoride reacts violently with toluene at 80 deg. Diisobutylaluminum hydride readily reduces di and mono. Diisobutylaluminum hydride is one of numerous organometallic compounds sold by american elements under the trade name ae organometallics for uses requiring nonaqueous solubility such as recent solar energy and water treatment applications. Dcm, thf, hexanes, heptane, toluene, and cyclohexane. The information in this document is based on the present state of our. Methylbenzene recommended use laboratory chemicals. Application diisobutylaluminum hydride solution 25 wt. Firstaid measures general advice if symptoms persist, call a physician.
Hazardous in case of skin contact irritant, of eye contact irritant, of ingestion, of inhalation. I t is used in pdcatalyzed reductive debromination of secondary alkyl bromides, odebenzylation and ring opening of perbenzylated furanosides and convenient in situ generation of hzrcp2cl from zrcp2cl2 and dibalh. Diisobutylaluminum hydride dibah is a pyrophoric liquid supplied undiluted or as a solution in a compatible hydrocarbon solvent. Use this link for bookmarking this species for future reference. N cis2vinylcyclohexylsuccin imide to 1cis2vinylcyclohexyl5hyd roxy2pyrrolidinone. Safety data sheet creation date 11jun2009 revision date 17jan2018 revision number 4 1. Reacts chemically with nitrogen oxides, or halogens to form nitrotoluene, nitrobenzene, and.